Top 10 Hotels in Northeast Missouri (from $80) 2026 - Competitive Prices

A large eye sculpture in a park surrounded by trees.

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Go beyond your typical stay in Northeast Missouri

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Our top choices for Northeast Missouri hotels

An indoor swimming pool with a view of the outside, a sign reading 'Depot Inn,' and a 'RAILROAD CROSSING' sign on the wall.

A hotel lobby with a reception desk, a coffee station, and seating areas.

A hotel lobby with a reception desk, seating area, and a sign for the general store.

A bedroom with a four-poster bed, a bedside table with a lamp, a desk with a telephone, and a bathroom with a bathtub and a hanging plant.

1. Depot Inn and Suites

La Plata

Guest highlights

Pool with billiard table
Short walk to nearby playground
Continental breakfast with new hot options

$83 nightly

$90 total

Oct 25 - Oct 26

Total with taxes and fees

A living room with a sofa, coffee table, and patterned rug. There are large windows with blinds, a chandelier, and a view of the outside.

A dining area with multiple tables and chairs, a kitchen area with a refrigerator and various kitchen items, and a window with curtains.

A building with a covered entrance, American flag, and a sign indicating it's open.

A hotel hallway with a patterned carpet, doors, and a sign indicating room number 101.

2. FairBridge Inn Express, Monroe City

Monroe City

Guest highlights

Short walk to nearby restaurants
Clean and inviting guest rooms
Comfortable bed with fresh linens

$84 nightly

$91 total

Oct 10 - Oct 11

Total with taxes and fees

A hotel room with a bed, a sofa, a desk, a chair, and a small table.

A bathroom with a sink, toilet, and bathtub. There is a towel rack with towels, a mirror, and a ceiling light.

A kitchenette with a coffee maker, toaster, microwave, and various kitchen utensils.

A hotel room with a bed, a desk with a computer, a chair, a TV, and a window with curtains.

3. Super 8 by Wyndham Macon

Macon

Guest highlights

Safe and plentiful parking available
Extremely clean bathroom with great shower
Quiet location with comfortable rooms

$79 nightly

$86 total

Oct 25 - Oct 26

Total with taxes and fees

A stainless steel ice dispenser with a blue button labeled 'PUSH FOR ICE' in a kitchen setting.

A motel with a sign advertising free continental breakfast and internet service.

A reception area with a counter, a trash bin, and a seating area with chairs.

A hotel room with two beds, green walls, and artwork.

4. Travelier Motel

Macon

Guest highlights

Friendly and helpful staff on hand
Comfortable beds for a restful night
Clean and affordable rooms available

$77 nightly

$83 total

Oct 2 - Oct 3

Total with taxes and fees

A compact kitchen with wooden cabinets, a coffee machine, and a dining area with metal chairs.

A neatly made bed with a brown quilted bedspread, a decorative pillow with a heart-shaped towel, and a bedside table with a lamp.

A living room with a black leather sofa, two black chairs, a potted plant, and a small table.

A hotel lobby with a black leather sofa, two bar stools, a reception desk, and a sign indicating no refund policy.

5. Americas Best Value Inn & Suites Macon at Sunset Dr

Macon

Guest highlights

Close to local coffee shops
Fresh-smelling bedding and bed
Clean and comfortable room

$68 nightly

$73 total

Oct 2 - Oct 3

Total with taxes and fees

A neatly made bed with a white quilt, a dark wooden headboard, a bedside lamp, a red chair, and a wall decoration.

A hotel lobby with a Christmas tree, red sofas, a wooden reception desk, and a sign for Simple Rewards Inn.

A long, narrow hallway with carpeted floors, doors on both sides, and a red chair in the distance.

A room with a large window, a red chair, and a wall-mounted air conditioner.

6. Prairie View Inn

Shelbina

$95 nightly

$104 total

Oct 2 - Oct 3

Total with taxes and fees

A wooden bridge with a rope railing in a forested area.

A wooden staircase with a railing, a door, and a ceiling with fluorescent lights.

A modern kitchen with wooden cabinets, stainless steel appliances, and a large island.

A spacious living room with a high ceiling, wooden beams, a fireplace, and a dining area with a table and chairs.

7. Lost Branch Lodge. Complete exterior remodel, spring 2026!

Brashear

Guest highlights

Perfect for family gatherings with space
Very well stocked kitchen with supplies
Extra spacious with games for all ages

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Vacation Rentals in Northeast Missouri

Cabin

A park with a pond, picnic tables, and a gazebo.

A grassy area with a picnic table and a dog.

A small, well-lit kitchen with a dining table, chairs, a refrigerator, a microwave, and a television mounted on the wall.

Cannon Dam Cabins

Perry

"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"

Aparthotel

A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

A modern living room with a grey sofa, a white armchair, a coffee table, and a patterned rug. There is a kitchen in the background with white cabinets and a black door.

A swimming pool with lounge chairs and a covered seating area.

A spacious bathroom with a large bathtub, a walk-in shower, and a vanity with a mirror.

Lighthouse Inn & Suites

Hannibal

"Wonderful place to stay!"

Cottage

A covered porch with a white door, two folding chairs, and a concrete walkway.

A kitchen with white cabinets, a granite countertop, a stainless steel refrigerator, a microwave, a toaster, and a coffee maker.

A modern kitchen with white cabinets, a black refrigerator, and a dining area with a blue table runner.

A living room with a sofa, a table, a TV, and a dining area with chairs.

Peaceful Missouri Cabin Rental on 55 Acres!

Canton

"This is a great place to stay if you want to get away from the city. Rural enough to be quiet, but within easy driving distance to a city. Also perfect if you just want to stay on the property and really get away from city life, just bring your groceries. "

Aparthotel

A compact living space with a sofa, a TV, a kitchen area with a fridge, microwave, and coffee maker, and a dining table.

A modern kitchen with a wooden island, bar stools, and a flat-screen TV.

A living room with a sofa, armchair, and coffee table. There is a staircase with a railing and a door in the background.

A black building with large windows, a covered porch with a flag, and potted plants.

The Mercantile on the Katy Trail

Hermann

"It’s an absolute must do! Such a cool little town right on the Katy Trail!"

Apartment

A spacious foyer with a grand staircase, a piano, and a large rug.

A backyard with a stone fire pit, two Adirondack chairs, and a hammock.

A spacious living room with a beige sofa, a dining area with a table and chairs, large windows, and a chandelier.

A hallway with wooden doors, a wall-mounted tree decoration, a small table with a plant, and a painting.

White House at Grand Central

Grand Center

"Staff was great and accommodating to my needs."

Apartment

A modern hotel lobby with a marble reception desk, a TV mounted on the wall, and a seating area with chairs and a sofa.

A swimming pool with lounge chairs, a bar area, and a building with multiple balconies.

A modern living room with a pool table, a seating area, and a large window offering a view of the outdoors.

A modern living area with a grey sofa, a glass coffee table, and a black leather sofa. There are large windows and a visible interior space beyond.

Landing Furnished Apartments - Central West End

Central West End

"We booked a two bedroom for three people and the 2nd bedroom didn't have a bed! Contacted property, which was very responsive, but they couldn't do anything since we booked through Hotels. com"

Vacation Home

A dining table with a clear glass top, surrounded by two chairs, a potted plant, and a set of white tableware.

A living room with two armchairs, a large wall clock, a wooden staircase, and a welcome sign.

A two-story brick house with a front porch, a stone foundation on one side, and a wooden deck on the other.

A modern living room with a blue sofa, a fireplace, a ceiling fan, and a TV mounted above the fireplace.

Forest Park Oasis | JZ Vacation Rentals

Kings Oak

"Great property with plenty of space. Nice sized dining room table for dinner. Beautiful family room and fire place. Nicely decorated. "

Apartment

A spacious room with a wooden dining table, chairs, a chandelier, and a bed with white bedding.

A spacious living area with a blue sofa, wooden flooring, and a chandelier.

A bedroom with a bed, a desk, a chair, a bench, and a ceiling fan.

A red deck with wicker furniture and a blue umbrella, overlooking a residential area with houses and a dome-shaped building.

Spacious 3-Bedroom with King Bed

Central West End

"Clean room nice area "

Cottage

A living room with a beige sofa, a coffee table, a TV mounted on the wall, and a chair.

A modern kitchen with white cabinets, a granite countertop, a built-in stove, a microwave, and a stainless steel refrigerator.

A compact living space with a dining area, a sofa, and a television.

Updated Missouri Cabin Rental on Large Farm

Canton

"The cabin rental was a great stay. Had some connection problems with the t.v. couldn't get past the check out date. The wifi was easy to hook up. The cabin was clean and smelled fresh. Did have some problems with ants on the countertop. Great place to stay, enjoyed our visit."

Apartment

A modern bedroom with a large bed, a sofa, and a fireplace.

A spacious living room with a sectional sofa, a coffee table, and a fireplace. There are large windows and a high ceiling.

A modern kitchen with white cabinets, a stainless steel refrigerator, a microwave, and a stove.

Hidden Gem | JZ Vacation Rentals

Central West End

Apartment

A wooden dock extending into a calm lake surrounded by lush greenery.

A room with a wooden floor, a patterned chair, a television mounted on the wall, and a kitchen area visible through an open door.

A swimming pool with lounge chairs and a house in the background.

A white two-story house with a wooden deck and a staircase leading to the front door.

Charming Berger Apt on 42-acre Farm w/ Pool Access

Berger

Apartment

A red building with a sign for 'Catala House' and a 'Massage House' sign.

A cozy loft-style living room with a brown leather sofa, a blue ottoman, and a patterned rug.

A red building with a balcony, a staircase, and outdoor seating with a blue umbrella.

A bedroom with a bed, a flat-screen TV mounted on the wall, a brick pillar, and a window with curtains.

New Melle Apartment Near Missouri Wine Country

Wentzville

"Apartment was wonderful! Very spacious and lots of furniture. Had a flat screen in the living room and bedroom that included Netflix and Prime. Air conditioner worked very well. Was very quiet and in a good location. Property manager was very friendly. There was even a very nice tea selection included with our stay. All amenities including, fridge, sinks, countertop burner, shower, washer, dryer, and toilet worked with no issues. All the dishes and mugs were clean. Plenty of towels to use during...

Apartment

A modern kitchen with a wooden ceiling, a dining area with stools, and a seating area with a bench.

An outdoor patio with wooden benches and a covered seating area, surrounded by a gravel path and a fence.

A bedroom with a wooden ceiling, two windows with blinds, a bed with a striped blanket, a bedside table, and a white fan.

A modern kitchen with a built-in stove, a sink, and a countertop. There is a window with blinds, a ceiling fan, and a small stool.

The Merlot Bungalow Defiance Tiny Home on Trail

Defiance

"We enjoyed our stay very much! The place was very cute and conveniently located to explore Defiance! We will look to stay here again in the future!"

Apartment

A kitchen with white cabinetry, wooden countertops, a dining table with checkered chairs, and a view of greenery outside.

A two-story house with a porch, a red door, and a sign advertising vacation rentals.

A living room with a red sofa, a checkered sofa, a wooden coffee table, and a cowhide rug. There is a white cabinet and a black pendant light.

A hallway with a wooden floor, a chandelier, framed pictures, a mirror, and a door labeled "Farmhouse."

'the Ruebling House' Historic Defiance Apartment!

Defiance

"This was are first family Vacation and are stay was amazing nice and clean with plenty of space. I would definitely recommend to a friend."

Apartment

A living room with a sofa, armchair, and coffee table. There is a ceiling fan, a TV mounted on the wall, and a window with blinds.

A modern kitchen with dark cabinets, a black refrigerator, a white stove, and a wooden floor.

A bedroom with a bed, a TV, a ceiling fan, and a hallway leading to another room.

A white door with a small mailbox and a mailbox with a bear figure on the front step.

Walk to Carondelet Park: Quiet Couple's Getaway

Carondelet

"We had a nice stay, close to things we wanted to do"

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Stay near popular Northeast Missouri attractions

The Saint Louis Zoo sign with vines on the wall.

St. Louis Zoo

9.2/10 (4,367 reviews)

In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.

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A cityscape with a prominent statue in the center, surrounded by various buildings and a large stadium.

Enterprise Center

8.8/10 (1,597 reviews)

Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.

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A baseball stadium with a large crowd, a prominent arch structure, and various advertisements.

Busch Stadium

9.4/10 (4,850 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art scene or attend a baseball game.

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A cityscape with a prominent arch structure, various high-rise buildings, and a large government building.

Dome at America’s Center

8.4/10 (1,229 reviews)

Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's fascinating museums and acclaimed art scene.

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A modern building with large glass windows, surrounded by a garden with red and pink tulips and purple flowers.

Forest Park

9.2/10 (3,389 reviews)

Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.

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A historic building with a large lawn, a flagpole with flags, and a clear blue sky.

St. Louis University

8.6/10 (526 reviews)

Explore the campus of St. Louis University as part of your travels around St. Louis. Wander around the area's picturesque gardens or experience its acclaimed theater scene.

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A tightrope walker balancing on a wire between buildings.

City Museum

9.0/10 (3,209 reviews)

This quirky children’s museum invites visitors to crawl through whales, climb into tree houses and whiz down three-story slides.

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America's Center Convention Complex

8.8/10 (306 reviews)

Learn about the events happening at America's Center Convention Complex during your trip to St. Louis. Experience the area's acclaimed art scene and great live music.

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Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri

Top Northeast Missouri Hotel Reviews

Drury Plaza Hotel St. Louis Union Station

8/10 Good

"The hotel was in a good location and right across from Union Station and its entertainment amenities. Staff was very friendly and gave me recommendations to visit around the city. At night, it is a bit isolated and would only recommend one drive to other areas instead of walking."

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent

"Clean room and very friendly staff,plus close to downtown"

The Westin St. Louis

10/10 Excellent

"Amazing property, staff was very friendly, great location!!"

21C Museum Hotel St Louis

10/10 Excellent

"Room clean. Staff friendly."

Pear Tree Inn St. Louis Airport

10/10 Excellent

"Stay here every time 24 hour fountain drinks and coffee in the lobby. We leave our car here till we return from the airport. They have a 24 hour shuttle no complaints."

Sonesta ES Suites St. Louis - Chesterfield

8/10 Good

"Very clean and worked well for us. Polite staff. Breakfast was good with several hot choices. We were there two nights and there was no housekeeping so ask for extra towels if needed. After our stay I got several phone calls from Sonesta asking for a review. I would rather get an e-mail. Otherwise, a good price and there was no cancellation fee."

Renaissance St. Louis Airport Hotel

10/10 Excellent

"Hotel is beautiful within itself"

The West End

10/10 Excellent

"The West End was exactly what I needed. An economical hotel in a great location. The lighting was not the best and I could have used a couple of more clothes hangers, but otherwise it had everything I needed for my stay in St. Louis."

The Cheshire

8/10 Good

"It’s a unique (the rooms were named after authors 😊), and interesting hotel. The staff was friendly and helpful, the room was nice, and the breakfast was good. The only down side was the parking situation. We paid $10/day and many of the parking spots were filled by restaurant patrons (who parked for free). It was somewhat frustrating to drive around looking for a spot only to find out the only available spot was in lowest level of parking garage."

More cheap stays in Northeast Missouri

Best Western St. Louis Inn

6224 Heimos Industrial Park Dr St. Louis MO

$79 nightly

$91 total

Oct 7 - Oct 8

Total with taxes and fees

Tru By Hilton St. Louis Downtown

1221 Locus Street St. Louis MO

$89 nightly

$105 total

Nov 1 - Nov 2

Total with taxes and fees

Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO

$90 nightly

$106 total

Oct 6 - Oct 7

Total with taxes and fees

9.2/10 Wonderful! (3,264 reviews)

The West End

4215 Lindell Blvd St. Louis MO

$106 nightly

$120 total

Oct 4 - Oct 5

Total with taxes and fees

8.6/10 Excellent! (659 reviews)

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

$119 nightly

$136 total

Oct 4 - Oct 5

Total with taxes and fees

8.2/10 Very Good! (1,000 reviews)

AC Hotel St. Louis Clayton

227 South Central Ave St. Louis MO

$135 nightly

$158 total

Oct 11 - Oct 12

Total with taxes and fees

Hotels in Northeast Missouri with star-rating

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Shelbina Vacation Rentals

Things to do in Northeast Missouri

Find hotels in Northeast Missouri, MO from $80

Upfront pricing

Treat yourself

Be picky

Go beyond your typical stay in Northeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Northeast Missouri hotels

1. Depot Inn and Suites

2. FairBridge Inn Express, Monroe City

3. Super 8 by Wyndham Macon

4. Travelier Motel

5. Americas Best Value Inn & Suites Macon at Sunset Dr

6. Prairie View Inn

7. Lost Branch Lodge. Complete exterior remodel, spring 2026!

Vacation Rentals in Northeast Missouri

Cannon Dam Cabins

Lighthouse Inn & Suites

Peaceful Missouri Cabin Rental on 55 Acres!

The Mercantile on the Katy Trail

White House at Grand Central

Landing Furnished Apartments - Central West End

Forest Park Oasis | JZ Vacation Rentals

Spacious 3-Bedroom with King Bed

Updated Missouri Cabin Rental on Large Farm

Hidden Gem | JZ Vacation Rentals

Charming Berger Apt on 42-acre Farm w/ Pool Access

New Melle Apartment Near Missouri Wine Country

The Merlot Bungalow Defiance Tiny Home on Trail

'the Ruebling House' Historic Defiance Apartment!

Walk to Carondelet Park: Quiet Couple's Getaway

Stay near popular Northeast Missouri attractions

St. Louis Zoo

Enterprise Center

Busch Stadium

Dome at America’s Center

Forest Park

St. Louis University

City Museum

America's Center Convention Complex

Learn more about Northeast Missouri

Top Northeast Missouri Hotel Reviews

Drury Plaza Hotel St. Louis Union Station

Pear Tree Inn St. Louis Near Union Station

The Westin St. Louis

21C Museum Hotel St Louis

Pear Tree Inn St. Louis Airport

Sonesta ES Suites St. Louis - Chesterfield

Renaissance St. Louis Airport Hotel

The West End

The Cheshire

More cheap stays in Northeast Missouri

Best Western St. Louis Inn

Tru By Hilton St. Louis Downtown

Pear Tree Inn St. Louis Airport

The West End

Hampton Inn St. Charles St. Peters

AC Hotel St. Louis Clayton

Hotels in Northeast Missouri with star-rating

Explore a world of travel with Expedia

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